Nine potentially modifiable risk factors may explain 2/3 of Alzheimer cases world-wide according to a meta-analysis of published studies. These risk factors include obesity, depression, hypertension, current smoking, type 2 diabetes (Asian), frailty, hyperhomocysteine, low educational achievement and carotid artery narrowing. There was no evidence suggesting significant association with occupational exposures. The authors concluded that effective interventions in diet, medications, biochemical exposures, psychological condition, pre-existing disease and lifestyle may decrease new incidence of Alzheimer’s disease.
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Xu W, Tan L, Wang HF, Jiang T, Tan MS, Tan L, Zhao QF, Li JQ, Wang J, Yu JT: Meta-analysis of modifiable risk factors for Alzheimer’s disease. J. Neurol. Neurosurg. Psychiatry [Epub ahead of print, Aug. 20, 2015; doi: 10.1136/jnnp-2015-310548.]
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http://www.ncbi.nlm.nih.gov/pubmed/26294005