Category Archives: Uncategorized

Abstract: “While many diseases of aging have been linked to the immunological system, immune metrics capable of identifying the most at-risk individuals are lacking. From the blood immunome of 1,001 individuals aged 8–96 years, we developed a deep-learning method based … Continue reading →

COVID and the brain: researchers zero in on how damage occurs. Nature News July 7, 2021. “Growing evidence suggests that the coronavirus causes ‘brain fog’ and other neurological symptoms through multiple mechanisms…. How COVID-19 damages the brain is becoming clearer. … Continue reading →

Makhani, N., Tremlett, H. The multiple sclerosis prodrome. Nat Rev Neurol (2021). https://doi.org/10.1038/s41582-021-00519-3 https://www.nature.com/articles/s41582-021-00519-3

Summary: “The molecular mechanisms accounting for the environmental risk factor stimulation of Alzheimer’s disease (AD) pathogenesis including traumatic brain injury, diabetes, and chronic cerebral hypoperfusion remain unclear. The BDNF/TrkB signaling pathway plays a critical role in neuronal synaptic plasticity and … Continue reading →

Abstract: “Though SARS-CoV-2 primarily targets the respiratory system, patients and survivors can suffer neurological symptoms. Yet, an unbiased understanding of the cellular and molecular processes affected in the brains of COVID-19 patients is still missing. Here, we profile 65,309 single-nucleus transcriptomes … Continue reading →

“Curiosity is what drives organisms to investigate each other and their environment. It is considered by many to be as intrinsic as hunger and thirst, but the neurobiological mechanisms behind curiosity have remained elusive. In mice, Ahmadlou et al. found … Continue reading →

https://www.nature.com/articles/s41582-021-00518-4.pdf

https://www.pnas.org/content/pnas/118/17/e2018995118.full.pdf  

Abstract This study aims to explore the psychosocial and behavioral problems of children and adolescents in the early stage of reopening schools. In this national cross-sectional study, a total of 11072 students from China were naturally divided into two groups … Continue reading →

In Parkinson disease (PD), pathological processes and neurodegeneration begin long before the cardinal motor symptoms develop and enable clinical diagnosis. In this prodromal phase, risk and prodromal markers can be used to identify individuals who are likely to develop PD, … Continue reading →