Category Archives: Uncategorized

Abstract: “In coronavirus disease 2019 [COVID-19], thrombus formation is related to the pathogenesis of acute respiratory distress syndrome [ARDS] and the progression of clinical symptoms. Severe damage to vascular endothelial cells and the associated cytokine storm after SARS-CoV-2 infection cause … Continue reading

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Abstract: “Most COVID-19 patients recovered with low mortality; however, some patients experienced long-term symptoms described as “long-COVID” or “Post-COVID syndrome” (PCS). Patients may have persisting symptoms for weeks after acute SARS-CoV-2 infection, including dyspnea, fatigue, myalgia, insomnia, cognitive and olfactory … Continue reading

Posted in Uncategorized | Comments Off on Pathophysiology of Post-COVID syndromes: a new perspective

Highlights Cognitive fatigue is explored with magnetic resonance spectroscopy during a workday Hard cognitive work leads to glutamate accumulation in the lateral prefrontal cortex The need for glutamate regulation reduces the control exerted over decision-making Reduced control favors the choice … Continue reading

Posted in Uncategorized | Comments Off on A neuro-metabolic account of why daylong cognitive work alters the control of economic decisions

Sulzer D, Antonini A, Leta V, Nordvig A, Smeyne RJ, Goldman JE, Al-Dalahmah O, Zecca L, Sette A, Bubacco L, Meucci O, Moro E, Harms AS, Xu Y, Fahn S, Ray Chaudhuri K. COVID-19 and possible links with Parkinson’s disease … Continue reading

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McMurray JC, May JW, Cunningham MW, Jones OY. Multisystem Inflammatory Syndrome in Children (MIS-C), a Post-viral Myocarditis and Systemic Vasculitis-A Critical Review of Its Pathogenesis and Treatment. Front Pediatr. 2020 Dec 16;8:626182. doi: 10.3389/fped.2020.626182. PMID: 33425823; PMCID: PMC7793714. https://pubmed.ncbi.nlm.nih.gov/33425823/

Posted in Uncategorized | Comments Off on Multisystem Inflammatory Syndrome in Children (MIS-C), a Post-viral Myocarditis and Systemic Vasculitis-A Critical Review of Its Pathogenesis and Treatment

(1) Banday AZ, Arul A, Vignesh P, Singh MP, Goyal K, Singh S. Kawasaki disease and influenza-new lessons from old associations. Clin Rheumatol. 2021 Jul;40(7):2991-2999. doi: 10.1007/s10067-020-05534-1. Epub 2021 Jan 2. PMID: 33387094; PMCID: PMC7778392. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778392/pdf/10067_2020_Article_5534.pdf and (2) Borrelli M, … Continue reading

Posted in Uncategorized | Comments Off on Kawasaki disease and influenza—new lessons from old associations

Abstract:  Background: Several autoimmune features occur during coronavirus disease 2019 (COVID-19), with possible implications for disease course, immunity, and autoimmune pathology. In this study, we longitudinally screened for clinically relevant systemic autoantibodies to assess their prevalence, temporal trajectory, and association … Continue reading

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Posted in Uncategorized | Comments Off on Congratulations to Dr. Lo at CUHK, Lasker Award Winner…

Abstract: “Considerable research effort has been made worldwide to decipher the immune response triggered upon severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, identify the drivers of severe and fatal COVID-19, and understand what leads to the prolongation of symptoms … Continue reading

Posted in Uncategorized | Comments Off on The immunology and immunopathology of COVID-19

Abstract: “Recessive or dominant inborn errors of type I interferon (IFN) immunity can underlie critical COVID-19 pneumonia in unvaccinated adults. The risk of COVID-19 pneumonia in unvaccinated children, which is much lower than in unvaccinated adults, remains unexplained. In an … Continue reading

Posted in Uncategorized | Comments Off on Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia