Category Archives: Uncategorized

The accumulation of certain forms of the tau protein in the brain is linked to loss of nerve cells, inflammation, and cognitive decline in Alzheimer’s disease and several other neurodegenerative diseases. Apolipoprotein-E (APOE), the strongest genetic risk factor for Alzheimer’s … Continue reading

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Abstract:   Because of historical associations between vaccines and Guillain-Barré syndrome (GBS), the condition was a prespecified adverse event of special interest for COVID-19 vaccine monitoring. To evaluate GBS reports to the Vaccine Adverse Event Reporting System (VAERS) and compare reporting … Continue reading

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Introduction: “The coverage of SARS-CoV-2 vaccination in large parts of the world, together with the high number of breakthrough infections, especially following the emergence of Omicron subvariants, makes hybrid immunity (resulting from vaccine and infection) common. Hybrid immunity, particularly after … Continue reading

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Abstract: “The impact of coronavirus disease 2019 (COVID-19) pandemic on patients with neurodegenerative diseases and the specific neurological manifestations of COVID-19 have aroused great interest. However, there are still many issues of concern to be clarified. Therefore, we review the … Continue reading

Posted in Uncategorized | Comments Off on Links between COVID-19 and Parkinson’s disease/Alzheimer’s disease: reciprocal impacts, medical care strategies and underlying mechanisms

Highlights There have been well-documented reports about the occurrence of parkinsonism after viral infections. 10 studies including 13 patients reported the development of parkinsonism in individuals who recovered from COVID-19 infection. The commonest symptom of parkinsonism reported in these individuals … Continue reading

Posted in Uncategorized | Comments Off on New-onset Parkinsonism as a Covid-19 infection sequela: A systematic review and meta-analysis

Abstract: Brain network dysfunction is increasingly recognised in Alzheimer’s disease (AD). However, the causes of brain connectivity disruption are still poorly understood. Recently, neuroinflammation has been identified as an important factor in AD pathogenesis. Microglia participate in the construction and … Continue reading

Posted in Uncategorized | Comments Off on Neuroinflammation is independently associated with brain network dysfunction in Alzheimer’s disease

Highlights • Identified 45 pairs of viral exposures associated with increased risk of NDDs • Replicated 22 of the viral exposures/NDD pairings • Replicated the previously reported Epstein-Barr and multiple sclerosis association • Follow-up shows significantly elevated risk of NDD … Continue reading

Posted in Uncategorized | Comments Off on Virus exposure and neurodegenerative disease risk across national biobanks

Semerdzhiev SA, Fakhree MAA, Segers-Nolten I, Blum C, Claessens MMAE. Interactions between SARS-CoV-2 N-Protein and α-Synuclein Accelerate Amyloid Formation. ACS Chem Neurosci. 2022 Jan 5;13(1):143-150. doi: 10.1021/acschemneuro.1c00666. Epub 2021 Dec 3. PMID: 34860005; PMCID: PMC8739828. https://pubmed.ncbi.nlm.nih.gov/34860005/

Posted in Uncategorized | Comments Off on Interactions between SARS-CoV-2 N-Protein and α-Synuclein Accelerate Amyloid Formation

Abstract: “Apart from common respiratory symptoms, neurological symptoms are prevalent among patients with COVID-19. Research has shown that infection with SARS-CoV-2 accelerated alpha-synuclein aggregation, induced Lewy-body-like pathology, caused dopaminergic neuron senescence, and worsened symptoms in patients with Parkinson’s disease (PD). … Continue reading

Posted in Uncategorized | Comments Off on Investigating neurological symptoms of infectious diseases like COVID-19 leading to a deeper understanding of neurodegenerative disorders such as Parkinson’s disease

Abstract: “Parkinson’s disease (PD) by its common understanding is a late-onset sporadic movement disorder. However, there is a need to recognize not only the fact that PD pathogenesis expands beyond (or perhaps to) the brain but also that many early-onset … Continue reading

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