Category Archives: Uncategorized

  Sigma non-opioid intracellular receptor 1 (Sigma-1R) is an intracellular chaperone protein residing on the endoplasmic reticulum at the mitochondrial-associated membrane (MAM) region. Sigma-1R is abundant in the brain and is involved in several physiological processes as well as in … Continue reading →

Abstract Background: Previous studies have shown that brain volume is negatively associated with cigarette smoking, but there is an ongoing debate about whether smoking causes lowered brain volume or a lower brain volume is a risk factor for smoking. We … Continue reading →

https://www.nejm.org/doi/full/10.1056/NEJMc2405495 Cow’s Milk Containing Avian Influenza A(H5N1) Virus — Heat Inactivation and Infectivity in Mice Published May 24, 2024 DOI: 10.1056/NEJMc2405495 In late March 2024, highly pathogenic avian influenza virus (HPAI) of the H5N1 subtype was for the first time detected … Continue reading →

https://www.cell.com/cell/fulltext/S0092-8674(24)00463-X

Abstract: Early-life adversities, whether prenatal or postnatal exposure, have been linked to adverse mental health outcomes later in life increasing the risk of several psychiatric disorders. Research on its neurobiological consequences demonstrated an association between exposure to adversities and persistent … Continue reading →

Reliable execution of precise behaviors requires that brain circuits are resilient to variations in neuronal dynamics. Genetic perturbation of the majority of excitatory neurons in HVC, a brain region involved in song production, in adult songbirds with stereotypical songs triggered … Continue reading →

https://www.nature.com/articles/d41586-024-01387-9 Researchers have mapped a tiny piece of the human brain in astonishing detail. The resulting cell atlas, which was described in Science and is available online, reveals new patterns of connections between brain neurons, as well as cells that wrap … Continue reading →

Multiple sclerosis (MS) is a global health concern affecting around 2.6 million people. It is characterised by neural inflammation, myelin breakdown and cognitive decline. Cognitive impairment, especially reduced cognitive processing speed (CPS), which affects up to 67% of MS patients … Continue reading →

SCH23390 is a widely used D1 dopamine receptor (D1R) antagonist that also elicits some D1R-independent effects. We previously found that the benzazepine, SKF83959, an analog of SCH23390, produces positive allosteric modulation of the Sigma-1 receptor (Sig1R). SCH23390 does not bind … Continue reading →

Abstract: Although B cells are implicated in multiple sclerosis (MS) pathophysiology, a predictive or diagnostic autoantibody remains elusive. In this study, the Department of Defense Serum Repository (DoDSR), a cohort of over 10 million individuals, was used to generate whole-proteome autoantibody … Continue reading →