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Dysregulation of the dopamine system is a well-established component of schizophrenia pathophysiology, with regional differences in dopamine targets thought to shape disease symptoms. Increased presynaptic striatal dopamine synthesis and release are among the most consistent findings in patients. These alterations … Continue reading

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Abstract: “Heart valve disease (HVD) is a complex entity made by different pathological processes that ultimately lead to the abnormal structure and disorganization of extracellular matrix proteins resulting to dysfunction of the leaflets. At its final evolutionary step, treatments are limited … Continue reading

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Abstract: “Strong evidence has emerged recently for the concept that herpes simplex virus type 1 (HSV1) is a major risk for Alzheimer’s disease. This concept proposes that latent HSV1 in brain of carriers of the type 4 allele of the … Continue reading

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Summary:  Light exerts a range of powerful biological effects beyond image vision, including effects on mood and learning. While the source of photic information affecting mood and cognitive functions is well established, via intrinsically photosensitive retinal ganglion cells (ipRGCs), the … Continue reading

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“…Immune cells normally pounce on intruding bacteria and viruses. But in multiple sclerosis (MS), immune cells target the nervous system instead. Now, researchers may have pinpointed a long-sought molecule called a self-antigen that provokes these attacks, pointing a way toward … Continue reading

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Abstract: “Persistence is central to outcomes across a range of domains: the harder you try, the further you get. Yet relatively little is known about the developmental origins of persistence. Here, (Lucca and Sommerville) highlight key reasons for a surge of interest in persistence in infancy … Continue reading

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Abstract: “Some research suggests that 40% of people in the vegetative state are misdiagnosed. This review investigates the frequency, nature and causes of reported misdiagnosis of patients in the vegetative state, focusing on the nature of the error. It is … Continue reading

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Structured Abstract INTRODUCTION “In 1853, Sydney Whiting wrote in his classic Memoirs of a Stomach, “…and between myself and that individual Mr. Brain, there was established a double set of electrical wires, by which means I could, with the greatest ease … Continue reading

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Abstract: “Physical exercise has beneficial effects on neurocognitive function, including hippocampus-dependent episodic memory. Exercise intensity level can be assessed according to whether it induces a stress response; the most effective exercise for improving hippocampal function remains unclear. Our prior work … Continue reading

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Abstract: “This paper examines the effect of both cumulative and transitory exposures to air pollution for the same individuals over time on cognitive performance by matching a nationally representative longitudinal survey and air quality data in China according to the … Continue reading

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