Category Archives: Uncategorized

https://www.nature.com/articles/s41583-020-0317-z.pdf “The advent of optogenetics — using light to activate opsins expressed in selected neuronal subtypes — has revolutionized the field of neuroscience. It has certain limitations, however, in part owing to the poor penetration of light through brain tissue, … Continue reading →

“When fruit flies endure sleeplessness, cells in their guts accumulate toxic molecules that break down their DNA. Similar toxins were spotted in sleep-deprived mice. And when the sleepless flies were given antioxidants that prevent such build-up, they reached a normal … Continue reading →

Summary ”Hardening of the arteries (atherosclerosis) was linked to dementia long ago, but subsequently, Alzheimer’s plaques and tangles have received more attention. A new proteome-wide association study unveils molecular links between intracranial atherosclerosis and dementia, independent of other pathologies, providing … Continue reading →

Modulation of the sigma-1 receptor-IRE1 Pathway Is Beneficial in Preclinical Models of Inflammation and Sepsis https://pubmed.ncbi.nlm.nih.gov/30728287/  

APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline https://www.nature.com/articles/s41586-020-2247-3

Understanding Parkinson’s Disease: video https://www.nature.com/articles/s41583-019-0254-x

The neuroinvasive potential of SARS‐CoV2 may play a role in the respiratory failure of COVID‐19 patients https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmv.25728

Nataf S: An alteration of the dopamine synthetic pathway is possibly involved in the pathophysiology of COVID-19. J Med Virol. [Epub ahead of print, Apr. 4, 2020; doi: 10.1002/jmv.25826]. https://www.ncbi.nlm.nih.gov/pubmed/32246784 https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmv.25826

Abstract: “Chronic low-grade inflammation has been observed in major depression and other major psychiatric disorders and has been implicated in metabolic changes that are commonly associated with these disorders. This raises the possibility that the effects of dysfunctional metabolism may … Continue reading →

The molecular mechanisms underlying the persistence of addiction remain largely unclear. Lepack and colleagues found that, with cocaine exposure, there is an intracellular accumulation of dopamine in neurons of a brain region called the ventral tegmental area. Dopamine associates with … Continue reading →