Category Archives: Uncategorized

Insular cortex neurons encode and retrieve specific immune responses Posted on January 13, 2022 by admin

Abstract: “Increasing evidence indicates that the brain regulates peripheral immunity, yet whether and how the brain represents the state of the immune system remains unclear. Here, we show that the brain’s insular cortex (InsCtx) stores immune-related information. Using activity-dependent cell … Continue reading →

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Multiple Sclerosis: inhibition of astrocyte-mediated neuroinflammation and protection against cingulum demyelination via S1P 1 -selective modulation Posted on January 6, 2022 by admin

Abstract:  “Ponesimod is a sphingosine 1-phosphate (S1P) receptor (S1PR) modulator that was recently approved for treating relapsing forms of multiple sclerosis (MS). Three other FDA-approved S1PR modulators for MS-fingolimod, siponimod, and ozanimod-share peripheral immunological effects via common S1P1 interactions, yet … Continue reading →

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SARS-CoV-2 Omicron variant replication in human respiratory tract ex vivo Posted on January 1, 2022 by admin

Abstract: “Emergence of SARS-CoV-2 variants of concern (VOC) with progressively increased transmissibility between humans is a threat to global public health. Omicron variant also evades immunity from natural infection or vaccines1. It is unclear whether its exceptional transmissibility is due … Continue reading →

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Illuminating the brain: an interview with Karl Deisseroth Posted on December 31, 2021 by admin

Neurophotonics associate editor Dr. Yeka Aponte interviewed Dr. Karl Deisseroth, professor of psychiatry and behavioral sciences and of bioengineering at Stanford University School of Medicine. Readers are also invited to view the interview in video format: https://bcove.video/3nRfJ5g Aponte Y. Illuminating … Continue reading →

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Association Between Immune Dysfunction and COVID-19 Breakthrough Infection After SARS-CoV-2 Vaccination Posted on December 29, 2021 by admin

“This cohort study found that full vaccination was associated with reduced risk of COVID-19 breakthrough infection, regardless of the immune status of patients. Despite full vaccination, persons with immune dysfunction had substantially higher risk for COVID-19 breakthrough infection than those … Continue reading →

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Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection Posted on December 17, 2021 by admin

https://www.nature.com/articles/s41591-021-01630-0

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Allosteric Modulation of the Sigma-1 Receptor Elicits Antipsychotic-like Effects Posted on December 8, 2021 by admin

Abstract: Allosteric modulation represents an important approach in drug discovery because of its advantages in safety and selectivity. SOMCL-668 is the first selective and potent sigma-1 receptor allosteric modulator, discovered in our laboratory. The present work investigates the potential therapeutic … Continue reading →

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Fluvoxamine for the Early Treatment of SARS-CoV-2 Infection: A Review of Current Evidence Posted on December 3, 2021 by admin

Abstract:  “SARS-CoV-2 infection causes COVID-19, which frequently leads to clinical deterioration and/or long-lasting morbidity. Academic and governmental experts throughout the USA met in 2021 to discuss the potential for use of fluvoxamine as early treatment of SARS-CoV-2 infection. Fluvoxamine is … Continue reading →

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1-year outcomes in hospital survivors with COVID-19 Posted on November 25, 2021 by admin

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01755-4/fulltext

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Safety and efficacy of fluvoxamine in COVID-19 ICU patients Posted on November 23, 2021 by admin

Abstract Fluvoxamine, an SSRI and sigma-1 receptor agonist, has so far shown promise in the prevention of COVID-19 progression as an early treatment option in 3 conducted trials. The aim of this study was to evaluate the safety and efficacy … Continue reading →

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