Category Archives: Uncategorized

Abstract: “Epstein-Barr virus (EBV) is a ubiquitous human lymphotropic herpesvirus with a well-established causal role in several cancers. Recent studies have provided compelling epidemiological and mechanistic evidence for a causal role of EBV in multiple sclerosis (MS). MS is the … Continue reading

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Background: Increasing evidence highlights that accumulating sitting time in prolonged bouts is detrimental to cardiometabolic health.   Objectives:  This systematic review aimed to compare the effects of fractionating prolonged sitting with frequent short bouts of standing and light-intensity walking on cardiometabolic health … Continue reading

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(1) Abbreviated Excerpt:  ”Most breast cancer cases show low concentrations of the breast cancer type 1 susceptibility protein (BRCA1). Surprisingly, only a small number of these patients have a mutated BRCA1 gene. Studies estimated that BRCA1 and BRCA2 mutations account … Continue reading

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Bierhansl, L., Hartung, HP., Aktas, O. et al. Thinking outside the box: non-canonical targets in multiple sclerosis. Nat Rev Drug Discov 21, 578–600 (2022). https://doi.org/10.1038/s41573-022-00477-5 https://www.nature.com/articles/s41573-022-00477-5

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Abstract: “Healthspan is the period of our life without major debilitating diseases. In the modern world where unhealthy lifestyle choices and chronic diseases taper the healthspan, which lead to an enormous economic burden, finding ways to promote healthspan becomes a … Continue reading

Posted in Uncategorized | Comments Off on Molecular Mechanisms of Exercise and Healthspan

1. Long-term changes in time spent walking and subsequent cognitive and structural brain changes in older adults. Best JR, Rosano C, Aizenstein HJ, Tian Q, Boudreau RM, Ayonayon HN, Satterfield S, Simonsick EM, Studenski S, Yaffe K, Liu-Ambrose T; Health, … Continue reading

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Abstract: “Inflammation in response to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection drives severity of coronavirus disease 2019 (COVID-19), with effective versus dysregulated responses influenced by host genetics. To understand mechanisms of inflammation, animal models that reflect genetic diversity and … Continue reading

Posted in Uncategorized | Comments Off on Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation and cytokine responses in COVID-19

Abbreviated Abstract: People who have COVID-19 can experience symptoms for months. Studies on long COVID in the population lack representative samples and longitudinal data focusing on new-onset symptoms occurring with COVID while accounting for pre-infection symptoms. We use a sample … Continue reading

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Abstract Background: Most children and adolescents infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain asymptomatic or develop a mild coronavirus disease 2019 (COVID-19) that usually does not require medical intervention. However, a small proportion of pediatric patients … Continue reading

Posted in Uncategorized | Comments Off on Epigenetic profiling linked to multisystem inflammatory syndrome in children (MIS-C)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340733/

Posted in Uncategorized | Comments Off on Virus infection as explanation for Kawasaki Disease and COVID-19 related Kawasaki-like symptoms