Category Archives: Uncategorized

Repurposing Sigma-1 Receptor Ligands for COVID-19 Therapy? Posted on November 3, 2022 by admin

Abstract: Outbreaks of emerging infections, such as COVID-19 pandemic especially, confront health professionals with the unique challenge of treating patients. With no time to discover new drugs, repurposing of approved drugs or in clinical development is likely the only solution. Replication … Continue reading →

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The effect of antidepressants on the severity of COVID-19 in hospitalized patients: A systematic review and meta-analysis Posted on November 3, 2022 by admin

Abstract Introduction: Clinical Depression and the subsequent low immunity is a comorbidity that can act as a risk factor for the severity of COVID-19 cases. Antidepressants such as Selective serotonin reuptake inhibitor and Serotonin-norepinephrine reuptake inhibitors are associated with immune-modulatory … Continue reading →

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Lack of evidence of significant homology of SARS-CoV-2 spike sequences to myocarditis-associated antigens Posted on November 3, 2022 by admin

Marrama D, Mahita J, Sette A, Peters B. Lack of evidence of significant homology of SARS-CoV-2 spike sequences to myocarditis-associated antigens. EBioMedicine. 2022 Jan;75:103807. doi: 10.1016/j.ebiom.2021.103807. Epub 2022 Jan 6. PMID: 34998242; PMCID: PMC8733122. https://pubmed.ncbi.nlm.nih.gov/34998242/

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Comparison of Multisystem Inflammatory Syndrome in Children-Related Myocarditis, Classic Viral Myocarditis, and COVID-19 Vaccine-Related Myocarditis in Children Posted on November 3, 2022 by admin

Abstract: Background Although rare, classic viral myocarditis in the pediatric population is a disease that carries significant morbidity and mortality. Since 2020, myocarditis has been a common component of multisystem inflammatory syndrome in children (MIS-C) following SARS-CoV-2 infection. In 2021, … Continue reading →

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Outcomes at least 90 days since onset of myocarditis after mRNA COVID-19 vaccination in adolescents and young adults Posted on November 3, 2022 by admin

Kracalik I, Oster ME, Broder KR, Cortese MM, Glover M, Shields K, Creech CB, Romanson B, Novosad S, Soslow J, Walter EB, Marquez P, Dendy JM, Woo J, Valderrama AL, Ramirez-Cardenas A, Assefa A, Campbell MJ, Su JR, Magill SS, … Continue reading →

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Gene–environment interactions in Alzheimer disease: the emerging role of epigenetics Posted on November 2, 2022 by admin

Abstract With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex aetiology that is likely to involve multiple susceptibility genes and environmental factors. The role of environmental factors is difficult to determine and, until a few … Continue reading →

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Report on the Recurrence of COVID-19 Symptoms Posted on October 28, 2022 by admin

Smith DM, Li JZ, Moser C, et al. Recurrence of Symptoms Following a 2-Day Symptom Free Period in Patients With COVID-19. JAMA Netw Open. 2022;5(10):e2238867. doi:10.1001/jamanetworkopen.2022.38867 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2797789

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COVID-19 and New Onset IgA Vasculitis: A Systematic Review of Case Reports Posted on October 23, 2022 by admin

  https://pubmed.ncbi.nlm.nih.gov/35691763/

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The emerging multifunctional roles of ERAP1, ERAP2 and IRAP between antigen processing and renin-angiotensin system modulation Posted on October 20, 2022 by admin

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1002375/full See also: D’Amico S, Tempora P, Lucarini V, Melaiu O, Gaspari S, Algeri M, Fruci D. ERAP1 and ERAP2 Enzymes: A Protective Shield for RAS against COVID-19? Int J Mol Sci. 2021 Feb 8;22(4):1705. doi: 10.3390/ijms22041705. PMID: 33567739; PMCID: … Continue reading →

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Endogenous PTEN-Induced Kinase 1 Regulates Dendritic Architecture and Spinogenesis Posted on October 12, 2022 by admin

Abstract: Mutations in PTEN-induced kinase 1 (PINK1) contribute to autosomal recessive Parkinson’s disease with cognitive and neuropsychiatric comorbidities. Disturbances in dendritic and spine architecture are hallmarks of neurodegenerative and neuropsychiatric conditions, but little is known of the impact of PINK1 … Continue reading →

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