Category Archives: Uncategorized

SARS-CoV-2 infects neurons and induces neuroinflammation in a non-human primate model of COVID-19 Posted on November 20, 2022 by admin

https://www.cell.com/cell-reports/pdf/S2211-1247(22)01434-6.pdf

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Acute and postacute sequelae associated with SARS-CoV-2 reinfection Posted on November 16, 2022 by admin

Abstract: First infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with increased risk of acute and postacute death and sequelae in various organ systems. Whether reinfection adds to risks incurred after first infection is unclear. Here we … Continue reading →

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Systematic analysis of drug-associated myocarditis reported in the World Health Organization pharmacovigilance database Posted on November 13, 2022 by admin

Nguyen, L.S., Cooper, L.T., Kerneis, M. et al. Systematic analysis of drug-associated myocarditis reported in the World Health Organization pharmacovigilance database. Nat Commun 13, 25 (2022). https://doi.org/10.1038/s41467-021-27631-8 https://www.nature.com/articles/s41467-021-27631-8  

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Myocarditis Higher With Moderna COVID Vaccine, but Overall Risk is Low Posted on November 9, 2022 by admin

Background:  Postmarketing evaluations have linked myocarditis to COVID-19 mRNA vaccines. However few population-based analyses have directly compared the safety of the 2 mRNA COVID-19 vaccines. Objectives: This study aimed to compare the risk of myocarditis, pericarditis, and myopericarditis between BNT162b2 … Continue reading →

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Bovine lactoferrin inhibits SARS-CoV-2 and SARS-CoV-1 by targeting the RdRp complex and alleviates viral infection in the hamster model Posted on November 8, 2022 by admin

Abstract: “Breast milk has been found to inhibit coronavirus infection, while the key components and mechanisms are unknown. We aimed to determine the components that contribute to the antiviral effects of breastmilk and explore their potential mechanism. Lactoferrin (Lf) and … Continue reading →

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Molecular mimicry of the receptor-binding domain of the SARS-CoV-2 spike protein: from the interaction of spike-specific antibodies with transferrin and lactoferrin to the antiviral effects of human recombinant lactoferrin Posted on November 6, 2022 by admin

Abstract: The pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection involves dysregulations of iron metabolism, and although the mechanism of this pathology is not yet fully understood, correction of iron metabolism pathways seems a promising pharmacological target. The previously … Continue reading →

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Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients Posted on November 6, 2022 by admin

https://www.science.org/doi/10.1126/science.abc6027

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The Role of Type I Interferons in the Pathogenesis and Treatment of COVID-19 Posted on November 6, 2022 by admin

Type I interferons (IFN-I) were first discovered over 60 years ago in a classical experiment by Isaacs and Lindenman, who showed that IFN-Is possess antiviral activity. Later, it became one of the first approved protein drugs using heterologous protein expression … Continue reading →

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Highly Specific Sigma Receptor Ligands Exhibit Anti-Viral Properties in SARS-CoV-2 Infected Cells Posted on November 6, 2022 by admin

Abstract (1) Background: There is a strong need for prevention and treatment strategies for COVID-19 that are not impacted by SARS-CoV-2 mutations emerging in variants of concern. After virus infection, host ER resident sigma receptors form direct interactions with non-structural … Continue reading →

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Myocarditis after COVID-19 mRNA vaccination: clinical observations and potential mechanisms Posted on November 4, 2022 by admin

“The risk of acute myocarditis associated with COVID-19 mRNA vaccination has garnered intense (social) media attention. However, myocarditis after COVID-19 mRNA vaccination is rare and usually resolves within days or weeks. Moreover, the risks of hospitalization and death associated with … Continue reading →

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