Category Archives: Uncategorized

A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases Posted on December 9, 2022 by admin

“…some genes associated with the risk of developing severe COVID appear to lower the risk of certain autoimmune diseases. For now, why that might be remains a mystery.  Verma A., et al., A Phenome-Wide Association Study of genes associated with COVID-19 … Continue reading →

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The effectiveness of coronavirus disease 2019 (COVID-19) vaccine in the prevention of post–COVID-19 conditions Posted on December 9, 2022 by admin

Marra, A., Kobayashi, T., Suzuki, H., Alsuhaibani, M., Hasegawa, S., Tholany, J., . . . Rizzo, L. (2022). The effectiveness of coronavirus disease 2019 (COVID-19) vaccine in the prevention of post–COVID-19 conditions: A systematic literature review and meta-analysis. Antimicrobial Stewardship … Continue reading →

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Long COVID: to investigate immunological mechanisms and sex/gender related aspects as fundamental steps for tailored therapy Posted on December 5, 2022 by admin

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462012/ Long COVID was detected in both adults and children and is characterised by immunological dysregulation. Autoimmune reactions in adult patients and allergic reactions in children appear to be critical factors. https://bit.ly/38RfSyT https://www.nature.com/articles/s41586-022-05349-x

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Risk factors for post-COVID-19 condition in previously hospitalised children Posted on December 5, 2022 by admin

Abstract Background: The long-term sequelae of coronavirus disease 2019 (COVID-19) in children remain poorly characterised. This study aimed to assess long-term outcomes in children previously hospitalised with COVID-19 and associated risk factors. Methods: This is a prospective cohort study of … Continue reading →

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Pre-existing chronic viral infection and reactivation on the development of long COVID Posted on December 3, 2022 by admin

Abstract Background: The presence and reactivation of chronic viral infections such as Epstein-Barr virus (EBV), cytomegalovirus (CMV) and human immunodeficiency virus (HIV) have been proposed as potential contributors to Long COVID (LC), but studies in well-characterized post-acute cohorts of individuals … Continue reading →

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Reactivated latent viruses after mild/asymptomatic COVID-19 Posted on December 1, 2022 by admin

Abstract Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic disease considered to be triggered by viral infections in a majority of cases. Symptoms overlap largely with those of post-acute sequelae of COVID-19/long-COVID implying common pathogenetic mechanisms. SARS-CoV-2 infection is … Continue reading →

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Fluvoxamine and long COVID-19; a new role for sigma-1 receptor (S1R) agonists Posted on November 29, 2022 by admin

Khani, E., Entezari-Maleki, T. Fluvoxamine and long COVID-19; a new role for sigma-1 receptor (S1R) agonists. Mol Psychiatry (2022). https://doi.org/10.1038/s41380-022-01545-3 https://www.nature.com/articles/s41380-022-01545-3

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The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies Posted on November 21, 2022 by admin

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) doubles with every 5 y of age from childhood onward. Circulating autoantibodies neutralizing IFN-α, IFN-ω, and/or IFN-β are found in ∼20% of deceased patients across age groups, and in … Continue reading →

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Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 Posted on November 21, 2022 by admin

Zhang Q, Bastard P, Liu Z, Le Pen J, Moncada-Velez M, Chen J, Ogishi M, Sabli IKD, Hodeib S, Korol C, Rosain J, Bilguvar K, Ye J, Bolze A, Bigio B, Yang R, Arias AA, Zhou Q, Zhang Y, Onodi … Continue reading →

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Interferon resistance of emerging SARS-CoV-2 variants Posted on November 21, 2022 by admin

Guo K, Barrett BS, Morrison JH, Mickens KL, Vladar EK, Hasenkrug KJ, Poeschla EM, Santiago ML. Interferon resistance of emerging SARS-CoV-2 variants. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2203760119. doi: 10.1073/pnas.2203760119. Epub 2022 Jul 22. PMID: 35867811; … Continue reading →

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