Category Archives: Uncategorized

Abstract: Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system underpinned by partially understood genetic risk factors and environmental triggers and their undefined interactions. Here we investigated the peripheral immune signatures of 61 monozygotic twin pairs discordant for … Continue reading

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Abstract: “Current knowledge on Multiple Sclerosis (MS) etiopathogenesis encompasses complex interactions between the host’s genetic background and several environmental factors that result in dysimmunity against the central nervous system. An old-aged association exists between MS and viral infections, capable of … Continue reading

Posted in Uncategorized | Comments Off on Multiple Sclerosis and SARS-CoV-2

Abstract: There is strong evidence for brain-related abnormalities in COVID-19. It remains unknown however whether the impact of SARS-CoV-2 infection can be detected in milder cases, and whether this can reveal possible mechanisms contributing to brain pathology. Here, we investigated brain … Continue reading

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Oaklander AL et al.: Peripheral Neuropathy Evaluations of Patients With Prolonged Long COVID. Neurol Neuroimmunol Neuroinflamm May 2022, 9 (3) e1146; DOI:10.1212/NXI.0000000000001146  https://nn.neurology.org/content/9/3/e1146

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Abstract: Epstein-Barr virus (EBV), also known as human herpesvirus 4, is a double-stranded DNA virus that is ubiquitous in 90-95% of the population as a gamma herpesvirus. It exists in two main states, latent infection and lytic replication, each encoding viral … Continue reading

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Novak P. et al., Multisystem Involvement in Post-Acute Sequelae of Coronavirus Disease 19.   Annals of Neurology 91(3): 367-379 (2022). https://doi.org/10.1002/ana.26286 https://onlinelibrary.wiley.com/doi/10.1002/ana.26286  

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Abstract Long-COVID refers to the lingering or protracted illness long after the acute illness. Depression, anxiety, fatigue, concentration and cognitive impairment appeared to be reported often in long COVID, psychosis seemed uncommon. Neuropsychiatric disorders in long COVID could be a … Continue reading

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Welberg, L. Strong evidence that Epstein–Barr virus infection triggers multiple sclerosis. Nat Neurosci 25, 131 (2022). https://doi.org/10.1038/s41593-022-01017-5 https://doi.org/10.1126/science.abj8222 (2022)

Posted in Uncategorized | Comments Off on Strong evidence that Epstein–Barr virus infection triggers multiple sclerosis

Abbrev. Abstract: Multiple sclerosis (MS) is a heterogenous autoimmune disease in which autoreactive lymphocytes attack the myelin sheath of the central nervous system (CNS). B lymphocytes in the cerebrospinal fluid (CSF) of MS patients contribute to inflammation and secrete oligoclonal … Continue reading

Posted in Uncategorized | Comments Off on Clonally Expanded B Cells in Multiple Sclerosis Bind EBV EBNA1 and GlialCAM

Multiple Early Factors Anticipate Post-Acute COVID-19 Sequelae Pre-proof…subject to change before final publication. SUMMARY “Post-acute sequelae of COVID-19 (PASC) represent an emerging global crisis. However, quantifiable risk- factors for PASC and their biological associations are poorly resolved. We executed a … Continue reading

Posted in Uncategorized | Comments Off on Multiple Early Factors Anticipate Post-Acute COVID-19 Sequelae