Category Archives: Uncategorized

Human Subjects Research and Potential Risks to Test Subjects Posted on June 18, 2023 by admin

Advance Announcement of Upcoming Research Seminar….   …………………………………………………………………….. Examples of Potential Risks to Subjects Potential risks fall into five broadly-defined categories. Research Compliance Services and the CPHS/IRB will weigh the potential risks of research against the potential benefits as part … Continue reading →

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Evaluation of Mask-Induced Cardiopulmonary Stress: A Randomized Crossover Trial Posted on June 18, 2023 by admin

“Thirty randomized participants (mean [SD] age, 26.1 [2.9] years; 15 women [50%]) completed the study. Wearing the N95 mask resulted in reduced respiration rate and oxygen saturation by pulse oximetry (Spo2) within 1 hour, with elevated heart rate (mean change, … Continue reading →

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Taurine deficiency as a driver of aging Posted on June 12, 2023 by admin

https://www.science.org/doi/10.1126/science.abn9257  

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Multiple sclerosis: 2023 update Posted on June 7, 2023 by admin

Multiple sclerosis (MS) is the most frequent inflammatory and demyelinating disease of the Central Nervous System (CNS). Significant progress has been made during recent years in preventing relapses by using systemic immunomodulatory or immunosuppressive therapies. However, the limited effectiveness of … Continue reading →

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Waves of Change……competition submission details coming soon… Posted on June 1, 2023 by admin

One of several Art demos available on YouTube to help you practise drawing and painting waves… https://www.youtube.com/watch?v=wsOf5Op4daA

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Dose-dependent changes in real-life affective well-being in healthy community-based individuals with mild to moderate childhood trauma exposure Posted on May 30, 2023 by admin

Abstract Background: Childhood trauma exposures (CTEs) are frequent, well-established risk factor for the development of psychopathology. However, knowledge of the effects of CTEs in healthy individuals in a real life context, which is crucial for early detection and prevention of … Continue reading →

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Cross-reactive EBNA1 immunity targets alpha-crystallin B and is associated with multiple sclerosis Posted on May 23, 2023 by admin

https://www.science.org/doi/10.1126/sciadv.adg3032

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CYP24A1 gene variant rs2762943 is associated with low serum 1,25-dihydroxyvitamin D levels in multiple sclerosis patients Posted on May 15, 2023 by admin

Abstract Background: Vitamin D is considered to play a role in multiple sclerosis (MS) etiopathogenesis. We recently identified a polymorphism in the CYP24A1 gene, rs2762943, that was associated with an increased MS risk. CYP24A1 encodes a protein involved in the … Continue reading →

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Serological response to vaccination in post-acute sequelae of COVID Posted on May 4, 2023 by admin

Abstract Background Individuals with post-acute sequelae of COVID (PASC) may have a persistence in immune activation that differentiates them from individuals who have recovered from COVID without clinical sequelae. To investigate how humoral immune activation may vary in this regard, … Continue reading →

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Modulation of the sigma-1 receptor pathway may be beneficial in preclinical models of inflammation and sepsis Posted on May 3, 2023 by admin

Rosen DA, Seki SM, Fernández-Castañeda A, Beiter RM, Eccles JD, Woodfolk JA, Gaultier A. Modulation of the sigma-1 receptor-IRE1 pathway is beneficial in preclinical models of inflammation and sepsis. Sci Transl Med. 2019 Feb 6;11(478):eaau5266. doi: 10.1126/scitranslmed.aau5266. Erratum in: Sci … Continue reading →

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