Category Archives: Uncategorized

Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer’s disease pathology Posted on September 28, 2023 by admin

DOI: https://doi.org/10.1016/j.cell.2023.08.039

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Von Economo Neuron Involvement in Social Cognitive and Emotional Impairments in Neuropsychiatric Disorders Posted on September 18, 2023 by admin

  https://neuro.psychiatryonline.org/doi/10.1176/appi.neuropsych.20220136

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Transforming Wound Management: Nanomaterials and Their Clinical Impact Posted on September 15, 2023 by admin

Wound healing is a complex process that can be further complicated in chronic wounds, leading to prolonged healing times, high healthcare costs, and potential patient morbidity. Nanotechnology has shown great promise in developing advanced wound dressings that promote wound healing … Continue reading →

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Cellular/Molecular Deficiency of Cullin 3, a Protein Encoded by a Schizophrenia and Autism Risk Gene, Impairs Behaviors by Enhancing the Excitability of Ventral Tegmental Area (VTA) DA Neurons Posted on September 6, 2023 by admin

Abstract The dopaminergic neuromodulator system is fundamental to brain functions. Abnormal dopamine (DA) pathway is implicated in psychiatric disorders, including schizophrenia (SZ) and autism spectrum disorder (ASD). Mutations in Cullin 3 (CUL3), a core component of the Cullin-RING ubiquitin E3 … Continue reading →

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Early-life Adversity and Genetics Associated With the Risk to Develop Psychiatric Illnesses Posted on September 6, 2023 by admin

https://doi.org/10.1176/appi.ajp.20230481

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Nutritional and metabolic factors in amyotrophic lateral sclerosis Posted on September 1, 2023 by admin

Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease that is classically thought to impact the motor system. Over the past 20 years, research has started to consider the contribution of non-motor symptoms and features of the disease, and how … Continue reading →

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Are microplastics spreading infectious disease? Posted on August 31, 2023 by admin

Are microplastics spreading infectious disease? Definitive evidence remains elusive, but early results suggest there’s good reason for vigilance. Carolyn BeansAuthors Info & Affiliations July 26, 2023 120 (31) e2311253120 https://doi.org/10.1073/pnas.2311253120 https://www.pnas.org/doi/10.1073/pnas.2311253120

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Fluvoxamine and Long Covid…..Role of Sigma-1 Posted on August 26, 2023 by admin

https://www.nature.com/articles/s41380-022-01545-3.pdf

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A conformational rearrangement of the SARS-CoV-2 host protein sigma-1 is required for antiviral activity Posted on August 23, 2023 by admin

The development of effective drugs to treat coronavirus infections remains a significant challenge for the scientific community. Recent evidence reports on the sigma-1 receptor (S1R) as a key druggable host protein in the SARS-CoV-1 and SARS-CoV-2 interactomes and shows a … Continue reading →

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Brain structure and phenotypic profile of superagers compared with age-matched older adults Posted on August 17, 2023 by admin

Abstract Background Cognitive abilities, particularly memory, normally decline with age. However, some individuals, often designated as superagers, can reach late life with the memory function of individuals 30 years younger. We aimed to characterise the brain structure of superagers and … Continue reading →

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