Category Archives: Uncategorized

Transmission of Alzheimer’s disease-associated microbiota dysbiosis and its impact on cognitive function: evidence from mice and patients Posted on November 1, 2023 by admin

The underlying cause of sporadic Alzheimer disease (AD) remains enigmatic, but an increased risk among spouses of people with AD has led to speculation of transmissibility. A mouse study now suggests that the transfer of microbiota could underlie this potential … Continue reading →

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Stress, Heritability, and Genetic Factors Influencing Depression, PTSD, and Suicidal Behavior Posted on October 30, 2023 by admin

https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.20230631

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Fungal microbiota sustains lasting immune activation of neutrophils and their progenitors in severe COVID-19 Posted on October 24, 2023 by admin

Abstract:  Gastrointestinal fungal dysbiosis is a hallmark of several diseases marked by systemic immune activation. Whether persistent pathobiont colonization during immune alterations and impaired gut barrier function has a durable impact on host immunity is unknown. We found that elevated … Continue reading →

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Multi-omics analysis of mucosal and systemic immunity to SARS-CoV-2 after birth Posted on October 19, 2023 by admin

Highlights • Infants and young children mount antibody responses that are durable for up to 300 days • Atypical innate response in blood: no inflammatory markers; high IFNα and chemokines • Robust upper respiratory tract antiviral and inflammatory responses • Single-cell … Continue reading →

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Differential response to SSRI versus Placebo and distinct neural signatures among data-driven subgroups of patients with major depressive disorder Posted on October 18, 2023 by admin

Abstract Objective: To identify data-driven subgroups in Major Depressive Disorder (MDD) in order to elucidate underlying neural correlates and determine if these subgroups have utility in predicting response to antidepressant versus placebo. Methods: Using 27 clinical measures at baseline of … Continue reading →

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Science fair notes for supervisors of student projects….Part 2. Posted on October 17, 2023 by admin
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Science fair notes for supervisors of student projects….Part 1. Posted on October 14, 2023 by admin

 

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Epigenetic signatures in antidepressant treatment response: a methylome-wide association study in the EMC trial Posted on October 10, 2023 by admin

Engelmann, J., Zillich, L., Frank, J. et al. Epigenetic signatures in antidepressant treatment response: a methylome-wide association study in the EMC trial. Transl Psychiatry 12, 268 (2022). https://doi.org/10.1038/s41398-022-02032-7

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Hormonal gatekeeping via the blood-brain barrier governs caste-specific behavior in ants Posted on October 5, 2023 by admin

Highlights • Single-cell RNA-seq identifies hormone-degrading esterase CfJhe localized to ant BBB • CfJhe expression is high in non-foraging Major-worker BBB cells leading to low JH3 • Ectopic expression of CfJhe in fly leads to loss of foraging-like behavior • … Continue reading →

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Subgroups of children with Kawasaki Disease Posted on September 30, 2023 by admin

https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(23)00166-9/fulltext

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