Author Archives: admin

The COVID-19 pandemic has left an indelible mark on every facet of our existence. In this issue of Acta Neuropsychiatrica, we embark on a comprehensive exploration of the pandemic’s multifaceted impact, drawing on the insights gleaned from four recent research … Continue reading →

https://www.nature.com/articles/d41586-023-03435

Human herpesvirus 6A (HHV-6A) and human herpesvirus 6B (HHV-6B), collectively termed HHV-6A/B, are neurotropic viruses that permanently infect most humans from an early age. Although most people infected with these viruses appear to suffer no ill effects, the viruses are … Continue reading →

Abstract Mitochondrial dysfunction has been suggested to contribute to Parkinson’s disease pathogenesis, though an understanding of the extent or exact mechanism of this contribution remains elusive. This has been complicated by challenging nature of pathway-based analysis and an inability simultaneously … Continue reading →

Abstract Background: Epstein-Barr virus (EBV) and human herpesvirus 6 (HHV-6) have been associated with multiple sclerosis (MS). Teriflunomide is an oral disease-modifying therapy approved for treatment of relapsing forms of MS. In the preclinical Theiler’s murine encephalitis virus model of … Continue reading →

The underlying cause of sporadic Alzheimer disease (AD) remains enigmatic, but an increased risk among spouses of people with AD has led to speculation of transmissibility. A mouse study now suggests that the transfer of microbiota could underlie this potential … Continue reading →

https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.20230631

Abstract:  Gastrointestinal fungal dysbiosis is a hallmark of several diseases marked by systemic immune activation. Whether persistent pathobiont colonization during immune alterations and impaired gut barrier function has a durable impact on host immunity is unknown. We found that elevated … Continue reading →

Highlights • Infants and young children mount antibody responses that are durable for up to 300 days • Atypical innate response in blood: no inflammatory markers; high IFNα and chemokines • Robust upper respiratory tract antiviral and inflammatory responses • Single-cell … Continue reading →

Abstract Objective: To identify data-driven subgroups in Major Depressive Disorder (MDD) in order to elucidate underlying neural correlates and determine if these subgroups have utility in predicting response to antidepressant versus placebo. Methods: Using 27 clinical measures at baseline of … Continue reading →