“Glucose homeostasis is not only regulated by the liver and pancreas; recent studies have shown that the hypothalamus also has a role in this process. However, whether changes in the hypothalamic regulation of glucose homeostasis contribute to the development of type 2 diabetes is not known. Cai and colleagues now show that increases in central transforming growth factor-β (TGFβ) levels induce hypothalamic inflammation and lead to hyperglycaemia and glucose intolerance – conditions that eventually may result in type 2 diabetes.” A useful commentary on the study done by Yan et al., Nature Medicine http:dx.doi.org/10.1038/nm.3616 (2014).
Welberg L: Sugar on the brain. Nature Reviews Neuroscience 15: 563 (2014); doi:10.1038/nrn3812

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