After accounting for non-independence between risk factors, Norton and colleagues report that approximately one third of Alzheimer’s diseases cases worldwide might be attributable to potentially modifiable risk factors. Alzheimer’s disease incidence might be reduced through improved access to education and use of effective methods targeted at reducing the prevalence of vascular risk factors (such as physical inactivity, smoking, midlife hypertension, midlife obesity, and diabetes) and depression. Relative reductions of 10% per decade in the prevalence of each of the seven risk factors could reduce the prevalence of Alzheimer’s disease in 2050 by 8•3% worldwide.
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Norton S, Matthews FE, Barnes DE, Yaffe K and Brayne C: Potential for primary prevention of Alzheimer’s disease: an analysis of population-based data. Lancet Neurology 13(8): 788-794 (2014).
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http://www.ncbi.nlm.nih.gov/pubmed/25030513

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