An analysis of more than 10,000 hospital admittance records has suggested that use of selective serotonin reuptake inhibitors (SSRIs) exacerbates haemorrhagic stroke. Patients previously taking SSRIs were more likely to have severe bleeding during haemorrhagic stroke, and were more likely to die within 30 days of admittance compared with patients not on SSRIs. However, these results were specific for haemorrhagic stroke as ischemic stroke patients showed no such increased risk.
Mortensen JK, Larsson H, Johnsen SP, Andersen G: Impact of Prestroke Selective Serotonin Reuptake Inhibitor Treatment on Stroke Severity and Mortality. Stroke 45: 2121-2123 (2014).