Bipolar disorder is considered to be a leading cause of global disability. Its biological basis is unknown, and its treatment is not optimal. Here, Harrison and colleagues review two recent areas of progress.” First, the discovery of risk genes and their implications, with a focus on voltage-gated calcium channels as part of the disease process and as a drug target. Second, facilitated by new technologies, it is increasingly apparent that the bipolar phenotype is more complex and nuanced than simply one of recurring manic and depressive episodes. One such feature is persistent mood instability, and efforts are underway to understand its mechanisms and its therapeutic potential. Bipolar disorder illustrates how psychiatry is being transformed by contemporary neuroscience, genomics, and digital approaches.”

Harrison PJ, Geddes JR, Tunbridge EM: The Emerging Neurobiology of Bipolar Disorder. Trends Neurosci. 41(1):18-30 (2018).

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