“Both preclinical studies and clinical trials have indicated that the combination of a selective serotonin reuptake inhibitor (SSRI) and a statin may have superior antidepressant effects compared with SSRI treatment alone. The authors sought to assess whether this beneficial effect can be generalized to a more heterogeneous population of SSRI users. In a nationwide cohort study that included all incident SSRI users in Denmark between 1997 and 2012, the authors compared people who had periods of concomitant use of SSRIs and statins with people who had periods of SSRI treatment alone. ….. The authors identified 872,216 incident SSRI users, of whom 113,108 (13.0%) used a statin concomitantly. Compared with SSRI treatment alone, the combined use of an SSRI and a statin was associated with a significantly lower risk for both psychiatric hospital contacts and psychiatric hospital contacts due to depression. Compared with SSRI treatment alone, the concomitant use of SSRIs and statins was not associated with significant increases in all-cause mortality or suicidal behavior.” The authors concluded that concomitant treatment with SSRIs and statins resulted in robust advantages compared with SSRIs alone.
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Köhler O, Gasse C, Petersen L, Ingstrup KG, Nierenberg AA, Mors O, Østergaard SD: The Effect of Concomitant Treatment with SSRIs and Statins: A Population-Based Study. American J. Psychiatry 173(8): 807-815 (2016).
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