“The dopamine system has been implicated in a number of psychiatric disorders, including depression and schizophrenia. Here, Grace describes evidence for disrupted afferent regulation of dopamine neuron firing in these disorders and considers the role of stress in driving this pathology.” This is a useful review for physicians interested in new concepts for psychotropic drug development.
Grace AA: Dysregulation of the dopamine system in the pathophysiology of schizophrenia and depression. Nature Reviews Neurosci. [Epub ahead of print, June 3, 2016; doi: 10.1038/nrn.2016.57].