Author Archives: admin

Abstract: “To date there is no treatment able to stop or slow down the loss of dopaminergic neurons that characterizes Parkinson’s disease. It was recently observed in a rodent model of Alzheimer’s disease that the interaction between the a7 subtype … Continue reading

Posted in Uncategorized | Comments Off on Neuroprotective and anti-inflammatory effects of a therapy combining agonists of nicotinic α7 and σ1 receptors in a rat model of Parkinson’s disease

“The newly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, a pandemic respiratory disease. Moreover, thromboembolic events throughout the body, including in the CNS, have been described. Given the neurological symptoms observed in a large majority of individuals … Continue reading

Posted in Uncategorized | Comments Off on Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19

“Do old and damaged cells remember what it was like to be young? That’s the suggestion of new study, in which scientists reprogrammed neurons in mouse eyes to make them more resistant to damage and able to regrow after injury—like … Continue reading

Posted in Uncategorized | Comments Off on Researchers restore lost sight in mice, offering clues to reversing aging

Excerpt from text: “…SARS-CoV-2 virions have in fact been observed in the human olfactory bulb (Nampoothiri et al., 2020). SARS-CoV particles have also been found in the human brain (Ding et al., 2004; Gu et al., 2005; Xu et al., … Continue reading

Posted in Uncategorized | Comments Off on SARS-CoV-2 receptors and entry genes are expressed in the human olfactory neuroepithelium and brain

Abstract Importance: Coronavirus disease 2019 (COVID-19) may lead to serious illness as a result of an excessive immune response. Fluvoxamine may prevent clinical deterioration by stimulating the σ-1 receptor, which regulates cytokine production. Objective: To determine whether fluvoxamine, given during … Continue reading

Posted in Uncategorized | Comments Off on Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19

Summary: “An aspirin to make CSCs go away: Cancer stem cells (CSCs) are tumor cells with stem cell-like qualities that promote tumor progression, adaption to stress, and resistance to chemotherapy. Bhattacharya et al. found that aspirin targets CSCs in a … Continue reading

Posted in Uncategorized | Comments Off on Aspirin enhances efficacy of chemotherapy via suppression of drug efflux pump ABCG2

https://www.nature.com/articles/d41586-020-02957-3

Posted in Uncategorized | Comments Off on Neanderthal DNA highlights complexity of COVID risk factors

Abstract: “The mechanisms by which prenatal immune activation increase the risk for neuropsychiatric disorders are unclear. Here, we generated developmental cortical interneurons (cINs)-which are known to be affected in schizophrenia (SCZ) when matured-from induced pluripotent stem cells (iPSCs) derived from … Continue reading

Posted in Uncategorized | Comments Off on Activated microglia cause metabolic disruptions in developmental cortical interneurons that persist in interneurons from individuals with schizophrenia

 Abstract:  “In less than 6 months, the severe acute respiratory syndrome-coronavirus type 2 (SARS-CoV-2) has spread worldwide infecting nearly 6 million people and killing over 350,000. Initially thought to be restricted to the respiratory system, we now understand that coronavirus … Continue reading

Posted in Uncategorized | Comments Off on COVID-19: A Global Threat to the Nervous System

Summary: ”The neuropeptide oxytocin is an important regulator of social behavior and is widely considered to reduce anxiety-related behaviors. However, growing evidence suggests that sometimes oxytocin increases anxiety. How can the same molecule have such different effects on behavior? Here … Continue reading

Posted in Uncategorized | Comments Off on Extrahypothalamic oxytocin neurons drive stress-induced social vigilance and avoidance