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https://www.science.org/doi/10.1126/science.abc6027

Posted in Uncategorized | Comments Off on Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

Type I interferons (IFN-I) were first discovered over 60 years ago in a classical experiment by Isaacs and Lindenman, who showed that IFN-Is possess antiviral activity. Later, it became one of the first approved protein drugs using heterologous protein expression … Continue reading

Posted in Uncategorized | Comments Off on The Role of Type I Interferons in the Pathogenesis and Treatment of COVID-19

Abstract (1) Background: There is a strong need for prevention and treatment strategies for COVID-19 that are not impacted by SARS-CoV-2 mutations emerging in variants of concern. After virus infection, host ER resident sigma receptors form direct interactions with non-structural … Continue reading

Posted in Uncategorized | Comments Off on Highly Specific Sigma Receptor Ligands Exhibit Anti-Viral Properties in SARS-CoV-2 Infected Cells

“The risk of acute myocarditis associated with COVID-19 mRNA vaccination has garnered intense (social) media attention. However, myocarditis after COVID-19 mRNA vaccination is rare and usually resolves within days or weeks. Moreover, the risks of hospitalization and death associated with … Continue reading

Posted in Uncategorized | Comments Off on Myocarditis after COVID-19 mRNA vaccination: clinical observations and potential mechanisms

Abstract: Outbreaks of emerging infections, such as COVID-19 pandemic especially, confront health professionals with the unique challenge of treating patients. With no time to discover new drugs, repurposing of approved drugs or in clinical development is likely the only solution. Replication … Continue reading

Posted in Uncategorized | Comments Off on Repurposing Sigma-1 Receptor Ligands for COVID-19 Therapy?

Abstract Introduction: Clinical Depression and the subsequent low immunity is a comorbidity that can act as a risk factor for the severity of COVID-19 cases. Antidepressants such as Selective serotonin reuptake inhibitor and Serotonin-norepinephrine reuptake inhibitors are associated with immune-modulatory … Continue reading

Posted in Uncategorized | Comments Off on The effect of antidepressants on the severity of COVID-19 in hospitalized patients: A systematic review and meta-analysis

Marrama D, Mahita J, Sette A, Peters B. Lack of evidence of significant homology of SARS-CoV-2 spike sequences to myocarditis-associated antigens. EBioMedicine. 2022 Jan;75:103807. doi: 10.1016/j.ebiom.2021.103807. Epub 2022 Jan 6. PMID: 34998242; PMCID: PMC8733122. https://pubmed.ncbi.nlm.nih.gov/34998242/

Posted in Uncategorized | Comments Off on Lack of evidence of significant homology of SARS-CoV-2 spike sequences to myocarditis-associated antigens

Abstract: Background Although rare, classic viral myocarditis in the pediatric population is a disease that carries significant morbidity and mortality. Since 2020, myocarditis has been a common component of multisystem inflammatory syndrome in children (MIS-C) following SARS-CoV-2 infection. In 2021, … Continue reading

Posted in Uncategorized | Comments Off on Comparison of Multisystem Inflammatory Syndrome in Children-Related Myocarditis, Classic Viral Myocarditis, and COVID-19 Vaccine-Related Myocarditis in Children

Kracalik I, Oster ME, Broder KR, Cortese MM, Glover M, Shields K, Creech CB, Romanson B, Novosad S, Soslow J, Walter EB, Marquez P, Dendy JM, Woo J, Valderrama AL, Ramirez-Cardenas A, Assefa A, Campbell MJ, Su JR, Magill SS, … Continue reading

Posted in Uncategorized | Comments Off on Outcomes at least 90 days since onset of myocarditis after mRNA COVID-19 vaccination in adolescents and young adults

Abstract With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex aetiology that is likely to involve multiple susceptibility genes and environmental factors. The role of environmental factors is difficult to determine and, until a few … Continue reading

Posted in Uncategorized | Comments Off on Gene–environment interactions in Alzheimer disease: the emerging role of epigenetics